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	Provedor de dados ABCL (1) Anais da ABC (AABC) (1) BJMBR (1) Autor BIASOLI,DEBORAH (1) BORGES,HELENA L. (1) Borja-Urby,Raúl (1) DELOU,JOÃO M.A. (1) Durán-Figueroa,Noé Valentín (1) Li,Xiangyun (1) Orozco-Romero,María de Jesús (1) Ponce-Castañeda,Martha Verónica (1) Wu,Jianhua (1) Xu,Chong (1) Zhu,Xiangxiang (1) Mais... Palavra-chave Retinoblastoma (3) Autophagy (2) 2-methyl-2-butanol (1) Antineoplastic agents (1) Biomarcadores (1) Cell cycle arrest (1) Cell death (1) Exosomas (1) Neoplasm (1) Phosphoinositide 3-kinase (PI3K)/Akt (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2018 (1) 2016 (2) País Brazil (2) Argentina (1) Idioma Inglês (2) Espanhol (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última 2-Methyl 2-butanol suppresses human retinoblastoma cells through cell cycle arrest and autophagy BJMBR Li,Xiangyun; Zhu,Xiangxiang; Xu,Chong; Wu,Jianhua. 2-Methyl-2-butanol (MBT) is a chemical compound from the group of alcohols more specifically pentanols, which has shown an excellent anti-cancer activity in our previous study. However, its mechanism of action remains unclear. The present study was designed to investigate the anti-cancer effect of MBT on human retinoblastoma cells. The results showed that the use of MBT leads to HXO-RB44 cell death but is cytotoxic to normal cells at higher concentrations. It showed a dose- as well as a time-dependent inhibition of HXO-RB44 cells. P27 is a cell cycle inhibitory protein, which plays an important role in cell cycle regulation whereas cyclin-B1 is a regulatory protein involved in mitosis. MBT increased the cell cycle arrest in a dose-dependent manner by... Tipo: Info:eu-repo/semantics/article Palavras-chave: 2-methyl-2-butanol; Retinoblastoma; Cell cycle arrest; Autophagy; Phosphoinositide 3-kinase (PI3K)/Akt. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000500605 Aislamiento y caracterización celular de exosomas de plasma para su uso como biomarcadores de diagnóstico ABCL Orozco-Romero,María de Jesús; Borja-Urby,Raúl; Ponce-Castañeda,Martha Verónica; Durán-Figueroa,Noé Valentín. Los exosomas son vesículas membranosas extracelulares esenciales en la comunicación intercelular a larga distancia, viajan en los fluidos corporales y entregan mensajes moleculares dirigidos a la mayoría de las células de todo el organismo. La liberación de mensajes vía exosomas ocurre en forma de ADN, ARN o proteínas; dicha liberación se ha asociado a diferentes condiciones fisiológicas normales y patológicas, como el cáncer. Por lo anterior, el aislamiento eficiente y caracterización celular de exosomas de plasma es clave para su uso como biomarcadores no invasivos de diversas enfermedades. En el presente estudio se purificaron exosomas a partir de muestras clínicas de plasmas de pacientes previamente diagnosticados con retinoblastoma y de individuos... Tipo: Info:eu-repo/semantics/article Palavras-chave: Biomarcadores; Exosomas; Retinoblastoma. Ano: 2016 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572016000400026 The Complex Link between Apoptosis and Autophagy: a Promising New Role for RB Anais da ABC (AABC) DELOU,JOÃO M.A.; BIASOLI,DEBORAH; BORGES,HELENA L.. ABSTRACT Physiological processes, as autophagy, proliferation and apoptosis are affected during carcinogenesis. Restoring cellular sensitivity to apoptotic stimuli, such as the antineoplastic cocktails, has been explored as a strategy to eliminate cancer cells. Autophagy, a physiological process of recycling organelles and macromolecules can be deviated from homeostasis to support cancer cells survival, proliferation, escape from apoptosis, and therapy resistance. The relationship between autophagy and apoptosis is complex and many stimuli can induce both processes. Most chemotherapeutic agents induce autophagy and it is not clear whether and how this chemotherapy-induced autophagy might contribute to resistance to apoptosis. Here, we review current... Tipo: Info:eu-repo/semantics/article Palavras-chave: Retinoblastoma; Neoplasm; Autophagy; Cell death; Antineoplastic agents. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602257 Registros recuperados: 3 Primeira ... 1 ... Última

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